Fluralaner Spot-on Solution (for Pets) 

1. Active Ingredient

Core active ingredient: Fluralaner (an isoxazoline insecticide and acaricide). It contains no unnecessary additives and features high purity. After topical administration, it rapidly penetrates the skin, hair and subcutaneous tissue, and is slowly absorbed into the bloodstream to exert a long-acting anthelmintic effect. It undergoes minimal metabolism and is mainly excreted in feces in its original form, imposing little burden on the pet's body with high safety.

2. Key Selling Points

• Long-lasting efficacy: Provides an extended duration of action against fleas and ticks, suitable for both dogs and cats (adaptive to different body sizes). A single administration every 12 weeks suffices for routine use; for cats infested with Dermacentor variabilis, administer every 8 weeks. No frequent application is needed, saving pet owners time.
• Rapid onset of action: Acts quickly against adult fleas (Ctenocephalides felis), rapidly blocks flea oviposition and disrupts their life cycle, reducing flea infestation from the source and alleviating Flea Allergic Dermatitis (FAD).
• Broad-spectrum anthelmintic effect: Effectively eliminates fleas and a variety of common ticks including those of the Ixodes genus, Rhipicephalus sanguineus, Haemaphysalis longicornis and Dermacentor variabilis, fully protecting pets' skin health.
• Safe and mild: Rare mild local irritation may occur, which resolves spontaneously with no obvious systemic adverse reactions. It can be used for breeding dogs, as well as pregnant and lactating bitches, boasting a wide scope of application. No cross-resistance with many commonly used anthelmintics, ensuring uncompromised efficacy.
• Easy to use: A topical spot-on solution with simple operation, no forced feeding required. Simply part the pet's fur and apply directly to the skin—high acceptability by pets and no hassle of oral medication administration.

3. Differences from Competitors

4. Clinical Cases

Case 1: Mixed flea and tick infestation in a dog

Pet information: 2-year-old Golden Retriever, 25kg, frequent outdoor activities. On presentation, adult fleas, flea eggs were found on the body, ticks attached to the postauricular and back areas, accompanied by pruritus and mild erythema (suspected flea allergic dermatitis).

Usage regimen: Canine formulation 3.57mL (1.0g fluralaner) at a dosage of ≥25mg per kg body weight, applied topically to the skin of the shoulder blade area on the back, administered every 12 weeks.

Efficacy: All fleas on the body died within 24 hours after administration, and ticks fell off gradually; pruritus and erythema relieved 3 days later; skin returned to normal with no new flea or tick infestation 1 week later; no recurrence of fleas or ticks during 3 months of continuous use. The pet was in good spirits with no adverse reactions.

Case 2: Dermacentor variabilis infestation in a cat

Pet information: 1-year-old British Shorthair, 3.5kg, often goes outdoors and contacts grassland. Dermacentor variabilis were found attached to the body, frequent scratching at the bite sites with mild skin damage.

Usage regimen: Feline formulation 0.4mL (112.5mg fluralaner) at a dosage of ≥40mg per kg body weight, applied topically to the skin at the base of the skull, administered every 8 weeks.

Efficacy: All ticks fell off within 48 hours after administration, and pruritus at bite sites reduced; skin damage healed with no secondary infection 1 week later; no recurrent tick infestation with periodic administration thereafter. The pet’s scratching behavior disappeared with stable skin condition.

Case 3: Long-term preventive use

Pet information: 1-year-old Toy Poodle, 8kg, indoor feeding with regular outdoor walking, no obvious parasitic infestation. The owner intended for long-term prevention of fleas and ticks.

Usage regimen: Canine formulation 1.79mL (0.5g fluralaner), administered every 12 weeks and applied to the skin of the hip area on the back.

Efficacy: No fleas or ticks were found on the pet’s body during 6 months of continuous use, with no skin irritation, allergy or other adverse reactions. The pet had smooth fur and good spirits, effectively avoiding the risk of parasitic infestation during outdoor activities.

Case 4: Lyme disease prevention and control in a dog (tick-borne transmission block)

Pet information: 3-year-old Labrador Retriever, 30kg, raised in a Lyme disease-endemic area in the US, often hikes outdoors with the owner and contacts grassland and woodlands. Recently presented with mild lethargy, anorexia and occasional lameness (suspected early symptoms of Lyme disease). Multiple ticks were found on the body upon physical examination, and early Lyme disease (infection with Borrelia burgdorferi transmitted by ticks) was confirmed by veterinary testing.

Usage regimen: First, symptomatic treatment with antibiotics (doxycycline) as directed by a veterinarian; meanwhile, canine formulation 3.57mL (1.0g fluralaner) at a dosage of ≥25mg per kg body weight, applied topically to the skin of the shoulder blade area on the back, administered every 12 weeks. Combined with environmental tick elimination, daily physical tick checks, and Lyme disease vaccination after veterinary consultation to establish a multi-modal prevention and control system.

Efficacy: All ticks on the body fell off within 48 hours after administration, effectively blocking the further transmission of Lyme disease spirochetes; lethargy and anorexia relieved, and lameness disappeared 1 week later; no recurrent tick infestation or Lyme disease during 6 months of continuous use with strict periodic administration. The pet’s mental state and appetite returned to normal, successfully avoiding the progression of Lyme disease to the chronic phase (causing joint swelling and kidney damage). This is consistent with the veterinary experts’ recommendation of year-round tick control for dogs, making this product a reliable tick-blocking option for dogs in Lyme disease-endemic areas.

(1) Applicable Scenarios

• Preventive scenario: For pets with regular outdoor activities (walking, contacting grassland/other pets) or indoor pets at risk of parasitic infestation, for long-term prevention of flea and tick infestation. It is recommended to administer every 12 weeks (every 8 weeks for the prevention of Dermacentor variabilis infestation in cats).
• Therapeutic scenario: For pets with confirmed flea/tick infestation (adults, eggs or attached ticks visible on the body) or accompanied by flea allergic dermatitis (pruritus, erythema, alopecia), for rapid elimination of parasites and alleviation of skin symptoms. Administer periodically until symptoms completely disappear, then switch to preventive dosage.
• Special scenario: Prevention/treatment of parasitic infestation in breeding dogs, pregnant and lactating bitches (use as per dosage); for pregnant and lactating cats, use only after veterinary evaluation to avoid risks.

(2) Dosage

(3) Administration Method (Topical use; avoid contact of the liquid with human and pet eyes at all times)

1. Preparation: Open the product sachet, take out the dropper, wear disposable gloves (to avoid direct contact with the liquid). Hold the dropper with the tip upward and twist the cap once to open (retain the cap for subsequent sealing).
2. Administration site: For dogs, apply to the skin between the shoulder blade and hip area on the back (apply at 2-3 spots to avoid liquid concentration); for cats, apply to the skin at the base of the skull (avoid the eye area to prevent licking).
3. Operation steps: Gently part the pet's fur to expose the intact skin, align the dropper tip with the skin, squeeze the dropper slowly to apply the liquid evenly on the skin surface. Ensure the liquid is in full contact with the skin and do not apply to the fur (which affects absorption).
4. Post-administration notes: Keep the application site dry for about 2-4 hours after administration. Avoid human contact with the application site and mutual licking between pets during this period. If the liquid splashes on the skin, wash immediately with soapy water; if it gets into the eyes, rinse thoroughly with a large amount of clean water.
5. Additional Precautions (for promotion scenarios)
6. Contraindications: Hypersensitivity to fluralaner or any component of this product; contraindicated for dogs ＜8 weeks of age/＜2kg and cats ＜11 weeks of age/＜2kg; do not apply to broken skin.
7. Storage: Store in a tightly sealed container, protected from light, in a cool and dry place, away from fire sources (this product is highly flammable). Keep out of reach of children.
8. Lyme disease prevention and control reminder: Lyme disease has become a major threat to dogs in many areas of the US, with ticks being the primary transmission vector. To effectively reduce the risk of dogs contracting Lyme disease and suffering from tick infestation, pet owners should adopt a multi-modal prevention and control approach: avoid tick-endemic areas and reduce the number of ticks in the surrounding environment; check the pet's body for ticks every day and remove them promptly if found; consult a veterinarian to evaluate whether the dog needs Lyme disease vaccination. Meanwhile, veterinary experts strongly recommend year-round tick control for all dogs. The long-acting anthelmintic effect of this product with a single administration every 12 weeks makes it an optimal choice for year-round tick control, providing continuous protection for dogs' health.